2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123915
    Antimalarial agent 20
    		Inhibitor
    Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC50 of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay.
    Antimalarial agent 20
  • HY-146045
    Antiparasitic agent-7
    		Inhibitor
    Antiparasitic agent-7 (compound 5d) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.85 μM. Antiparasitic agent-7 also has certain cytotoxicity against HepG2 (CC50 = 10.61 μM).
    Antiparasitic agent-7
  • HY-116448R
    Metaflumizone (Standard)
    		Inhibitor
    Metaflumizone (Standard) is the analytical standard of Metaflumizone. This product is intended for research and analytical applications. Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker.
    Metaflumizone (Standard)
  • HY-B1282AR
    Sulfaquinoxaline sodium salt (Standard)
    		Inhibitor
    3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA.
    Sulfaquinoxaline sodium salt (Standard)
  • HY-168732
    MCG-02
    		Inhibitor
    MCG-02 is the inhibitor for cruzain (CRZ) and cathepsin L-like protease (CATL), that inhibits the CRZ in Trypanosoma cruzi and CATL in Trypanosoma brucei with the IC50 0.2 μM and 0.02 μM.
    MCG-02
  • HY-148216
    HBPC–GSH
    		Inhibitor
    HBPC-GSH is a glyoxalase (Glo) inhibitor (cGloI IC50=0.6 μM; cGloII IC50=1.6 μM), a glutathione derivative. HBPC-GSH can be used in antimalarial research.
    HBPC–GSH
  • HY-N8476
    Sahandol
    		Inhibitor
    Sahandol is a diterpene, that can be isolated from Salvia sahendica. Sahandol shows antiplasmodial, antitrypanosomal, and cytotoxic activities.
    Sahandol
  • HY-B0094S
    Artemisinin-d3
    		Activator
    Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
    Artemisinin-d<sub>3</sub>
  • HY-W777442
    Cletoquine-d4 Oxalate
    Cletoquine-d4 Oxalate is the deuterium labeled Cletoquine (oxalate) (HY-135810A). Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment.
    Cletoquine-d<sub>4</sub> Oxalate
  • HY-138074
    Milbemycin A4 oxime
    Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
    Milbemycin A4 oxime
  • HY-115249R
    Metronidazole acetic acid (Standard)
    		Inhibitor
    Metronidazole acetic acid (Standard) is the analytical standard of Metronidazole acetic acid. This product is intended for research and analytical applications. Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa.
    Metronidazole acetic acid (Standard)
  • HY-147549
    Antitrypanosomal agent 6
    		Inhibitor
    Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA.
    Antitrypanosomal agent 6
  • HY-N0941R
    beta-Mangostin (Standard)
    		Inhibitor
    beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).
    beta-Mangostin (Standard)
  • HY-145233
    PfPKG-IN-1
    		Inhibitor
    PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).
    PfPKG-IN-1
  • HY-W011241
    Cinchonine hydrochloride
    		Inhibitor
    Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells.
    Cinchonine hydrochloride
  • HY-Y1825R
    Benzimidazole (Standard)
    		Inhibitor
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Benzimidazole (Standard)
  • HY-147198
    Antimalarial agent 13
    		Inhibitor
    Antimalarial agent 13 (Compound 1) is a potent antimalarial agent. Antimalarial agent 13 shows inhibition with EC50 values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively.
    Antimalarial agent 13
  • HY-B0937S
    Amprolium-d7 bromide hydrobromide
    		Inhibitor
    Amprolium-d7 (bromide hydrobromide) is a deuterium-labeled of Amprolium (HY-B0937). Amprolium-d7 (bromide hydrobromide) is a coccidiostat used in poultry, is a thiamine analog, and blocks the thiamine transporter of Eimeria species.
    Amprolium-d<sub>7</sub> bromide hydrobromide
  • HY-B0147S
    Pefloxacin-d5
    		Inhibitor 98.33%
    Pefloxacin-d5 (Pefloxacinium-d5) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies.
    Pefloxacin-d<sub>5</sub>
  • HY-147850
    JMI-346
    		Inhibitor
    JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQS (3D7; IC50=13 µM) and CQR (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent.
    JMI-346
Parasite Isoform Comparison

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